RNAi targeting Caenorhabditis elegans α-arrestins has little effect on lifespan
نویسندگان
چکیده
منابع مشابه
RNAi targeting α - arrestins marginally Caenorhabditis elegans affects lifespan
α-arrestins are a family of proteins that are implicated in multiple Background: biological processes, including metabolism and receptor desensitization. Here, we sought to examine the roles of α-arrestins in the longevity Methods: of through an RNA interference screen. We Caenorhabditis elegans Results: found that knocking down each of 24 out of total 29 α-arrestins had C. elegans small or no ...
متن کاملRNAi targeting Caenorhabditis elegans α-arrestins has small or no effects on lifespan
Background: α-arrestins are a family of proteins that are implicated in multiple biological processes, including metabolism and receptor desensitization. Methods: Here, we sought to examine the roles of α-arrestins in the longevity of Caenorhabditis elegans through an RNA interference screen. Results: We found that knocking down each of 24 out of total 29 C. elegans α-arrestins had small or no ...
متن کاملRNAi targeting α - arrestins marginally
α-arrestins are a family of proteins that are implicated in multiple Background: biological processes, including metabolism and receptor desensitization. Here, we sought to examine the roles of α-arrestins in the longevity Methods: of through an RNA interference screen. We Caenorhabditis elegans Results: found that knocking down each of 24 out of total 29 α-arrestins had C. elegans small or no ...
متن کاملthe Caenorhabditis elegans lifespan machine
nAture methods | ADVANCE ONLINE PUBLICATION | the measurement of lifespan pervades aging research. Because lifespan results from complex interactions between genetic, environmental and stochastic factors, it varies widely even among isogenic individuals. the actions of molecular mechanisms on lifespan are therefore visible only through their statistical effects on populations. indeed, survival ...
متن کاملThe RNAi Inheritance Machinery of Caenorhabditis elegans.
Gene silencing mediated by dsRNA (RNAi) can persist for multiple generations in Caenorhabditis elegans (termed RNAi inheritance). Here we describe the results of a forward genetic screen in C. elegans that has identified six factors required for RNAi inheritance: GLH-1/VASA, PUP-1/CDE-1, MORC-1, SET-32, and two novel nematode-specific factors that we term here (heritable RNAi defective) HRDE-2 ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: F1000Research
سال: 2017
ISSN: 2046-1402
DOI: 10.12688/f1000research.12337.4